Transcriptional control: Repression by local chromatin modification

Transcriptional control: Repression by local chromatin modification

It is becoming increasingly clear that chromatin modification plays a fundamental part in transcriptional control. Recent studies provide new insights into how transcriptional repressors, in addition to blocking activators, may recruit repression complexes that include chromatin modification factors.

Repression of Smad4 transcriptional activity by SUMO modification.

Smad4 plays a key role in TGF-beta (transforming growth factor beta)/Smad-mediated transcriptional responses. We show that Smad4 is sumoylated both in vivo and in vitro. Recent studies showed that sumoylation of Smad4 regulated its stability, but the effect of sumoylation on the intrinsic transcriptional activity of Smad4 was not defined. We show that overexpression of SUMO (small ubiquitin-rel...

Transcriptional Repression by BKLF Role for SUMO Modification in Facilitating

A role for SUMO modification in transcriptional repression and activation.

Since the discovery of the SUMO (small ubiquitin-related modifier) family of proteins just over a decade ago, a plethora of substrates have been uncovered including many regulators of transcription. Conjugation of SUMO to target proteins has generally been considered as a repressive modification. However, there are now a growing number of examples where SUMOylation has been shown to activate tr...

Control of NF-kappaB-dependent transcriptional responses by chromatin organization.

A large number of genes have been positively selected and recruited to participate in various phases of the inflammatory response triggered by microbial stimuli. Because of the complexity of the response, the many phases in which it is deployed, and the many "flavors" in which it appears (depending on quality and intensity of the stimulus as well as the target organ), very elaborated mechanisms...